Predicting the Within-Host Dynamics of Tuberculosis
نویسندگان
چکیده
We present a within-host model for tuberculosis (TB) infections, which directly models the bacterial load over the course of the infection. This allows for a future multi-scale model which can make use of the link between pathogen load and transmission potential of an infected host. By modelling the interactions between the host immune system, the invading bacteria and granulomas which are characteristic of TB, we were able to reproduce some of the major traits of the disease. The model recreates the distribution of latent and active infections and maintains an accurate dose dependence.
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